Analysis of Animal Models of Cervical Spondylotic Radiculopathy Based on Characteristics of Clinical Symptoms of Chinese and Western Medicine
10.13422/j.cnki.syfjx.20230349
- VernacularTitle:基于中西医临床病证特点的神经根型颈椎病动物模型分析
- Author:
Yushi CUI
1
;
Yun GAO
1
;
Mingyuan WANG
1
;
Shuai ZHANG
1
;
Shengping YANG
1
;
Xiaoyu LI
1
;
Xin YAN
1
Author Information
1. Eye Hospital，China Academy of Chinese Medical Sciences，Beijing 100040，China
- Publication Type:Journal Article
- Keywords:
cervical spondylotic radiculopathy;
animal model;
combination of Chinese and Western medicine;
combination of disease and syndrome;
clinical guidelines;
anastomosis;
cervical degenerative diseases
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(14):219-225
- CountryChina
- Language:Chinese
-
Abstract:
With the acceleration of social rhythm， the progress of science and technology， and the increase of the number of phubbers， the incidence of cervical degenerative diseases is also increasing year by year. Cervical spondylotic radiculopathy（CSR）， as one of the diseases induced by cervical degeneration， has seriously affected people's quality of life and physical and mental health. Traditional Chinese medicine（TCM） is effective in the treatment of CSR， but the theoretical and basic experimental evidence is not sufficient， and the current formulation standard of animal model is not unified. Therefore， based on the clinical guidelines of Chinese and Western medicine for CSR and the characteristics of the disease and syndrome， the author systematically summarized and analyzed the existing animal models， and found that the existing models of microvascular clamp nerve root compression method had a poor agreement with the the Chinese and Western medical guidelines， while the modeling methods of spinal canal insertion， autologous bone insertion compression， stainless steel column compression， and fixed frame cervical degeneration reflected a high degree of agreement in the Western medical guidelines. However， the Chinese medical diagnostic criteria were poorly matched. This indicates that the existing animal models of this disease show few TCM syndrome elements， and lack information collection and evaluation in animal behavioral evaluation similar to the four diagnoses of TCM. In conclusion， this paper aims to systematically evaluate the current status of animal model establishment of CSR based on the concept of combination of disease and syndrome， so as to provide a theoretical basis for the model establishment of CSR that is more consistent with clinical characteristics and symptoms of Chinese and Western medicine.
