Primary Research and Etiological Implication of Congenital Clubfoot-like Model at Pathological and Molecule Level
- VernacularTitle:类先天性马蹄足动物模型胚胎病理初步研究及病因学意义
- Author:
Yanli JIA
;
Shixin DU
;
Gefei LIU
- Publication Type:Journal Article
- Keywords:
foot deformities, congenital, retinoic acid, apoptosis
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(8):733-735
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible correlations under the interaction of multi-genes action at different stages and analyze the primary histophotomacrographic changes of hind buds tissue in congenital clubfoot and the pathodynamic developmental procedure.MethodsSeventy-seven female Wistar rats were administered with retinoic acid on the 10th day after pregnancy. And the hindlimb, buds and spinal cord were detected through transmission electron microscopic and molecular biological experiments.ResultsThere was clubfoot-like deformity in 61.8% of the experimental animals. Persistence of the embryonic position of the talus and tibia in fetuses was observed. Poor overlapping between talus and calcaneus was seen. Cell apoptosis at the anterior corner of spinal cord and hind buds were seen.ConclusionCongenital clubfoot deformities appear at early stage and exaggerate along with developmental procedure.
