Effect of Yujin on Cerebral Functions of Acute Hypoxia Mice
- VernacularTitle:郁金对低张性缺氧小鼠脑功能的影响
- Author:
Zonghua LI
;
Feng LI
;
Jingchun HE
;
Xin GUO
;
Lijuan ZHAO
- Publication Type:Journal Article
- Keywords:
Yujin, hypoxia, brain
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(8):710-711
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Yujin on cerebral function of acute hypoxia mice.MethodsThe acute hypoxia mice model was reproduced by cutting heads and establishing normal-pressure and closed hypoxic experimental settings. In yujin groups, the mice were treated with Yujin at the doses of 10 g/kg, 20 g/kg, 40 g/kg respectively through the intragastric tubes everyday. 6 days later, the mice survival time, the open-mouth times after cutting heads and the breathing time were observed. The activity of superoxide dismutase (SOD) and content of maleic dialdehyde (MDA) in cerebral tissues were measured. The morphological changes of the cerebral tissues under the microscope were examined.ResultsYujin could significantly prolong the survival time ( P<0.001) and the breathing time and increase the open-mouth times ( P<0.05～0.001), increase the activity of SOD ( P<0.001) and decrease the content of MDA ( P<0.01～0.001) in cerebral tissues. Compared with control group, the Yujin group mice had no obvious pathological alteration except some cerebral vascular dilatation.ConclusionYujin has an obvious protective effect on cerebral tissues of acute hypoxia mice.
