A Case of Pendipronil(R) Poisoning Treated by Hemoperfusion and Methylene Blue.
- Author:
Byung Kon JUNG
1
;
Ji Kyum KIM
;
Young Kwon PAK
;
Sung Ho PARK
;
Kyung Wook KIM
Author Information
1. Department of Internal Medicine, Kwangmyung Sung-Ae General Hospital, Kwangmyung, Korea.
- Publication Type:Case Report
- Keywords:
Pendipronil;
Methylene blue;
Methemoglobinemia;
Hemoperfusion
- MeSH:
Adult;
Anemia, Hemolytic;
Cellulose;
Central Nervous System;
Charcoal;
Cyanosis;
Dyspnea;
Eating;
Female;
Gastric Lavage;
Headache;
Hemoperfusion*;
Humans;
Korea;
Lung;
Methemoglobinemia;
Methylene Blue*;
Mouth;
Nausea;
Nose;
Pharynx;
Poaceae;
Poisoning*;
Propanil;
Psychomotor Agitation;
Solanum tuberosum;
Suicide;
Sulfhemoglobinemia;
Vomiting;
Zea mays
- From:Korean Journal of Nephrology
2000;19(6):1150-1153
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pendipronil(R) overdose is uncommon in Korea. Pendipronil(R) is a selective herbicide used to control most annual grasses and certain broadleaf weeds in field corn, potatoes, rice, etc. and is the substance including pendimethalin and propanil. Pendimethalin is slightly to practically nontoxic by ingestion but may be mildly to moderately irritating to the linings of the mouth, nose, throat, and lungs. Propanil toxicity is evidenced by varying clinical pictures ranging from deep cyanosis in an otherwise alert normal appearing individual to restlessness, dyspnea, extensive hemolytic anemia, methemoglobinemia, sulfhemoglobinemia and serious central nervous system dysfunction. For the treatment of methemoglobinemia, gastric lavage, activated charcoal, methylene blue and exchange transfusion should be used. We experienced a case of acute massive Pendipronil(R) intoxication in 31 years old woman due to voluntary ingestion of 48g of this drug as a suicide attempt. A moderate methemoglobinemia developed, accompanied by drowsy mental status, nausea, vomiting, headache, intensive cyanosis. The patient recovered completely after intravenous methylene blue injection and cellulose coated hemoperfusion charcoal (Adsorba 300C(R)) and conservative treatment.
