Protective efficacy of commercial inactivated Newcastle disease virus vaccines in chickens against a recent Korean epizootic strain.
- Author:
Woo Jin JEON
1
;
Eun Kyoung LEE
;
Young Jeong LEE
;
Ok Mi JEONG
;
Yong Joo KIM
;
Jun Hun KWON
;
Kang Seuk CHOI
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Newcastle disease; protection; vaccination; virus shedding
- MeSH: Administration, Intranasal; Animals; Chickens; Cloaca/virology; Disease Outbreaks/prevention & control/*veterinary; Korea; Newcastle Disease/*immunology/prevention & control; Newcastle disease virus/*immunology; Ophthalmic Solutions; Poultry Diseases/*immunology/prevention & control; *Vaccines, Inactivated/administration & dosage; Viral Vaccines/*administration & dosage; Virus Shedding/drug effects
- From:Journal of Veterinary Science 2008;9(3):295-300
- CountryRepublic of Korea
- Language:English
- Abstract: Despite the intensive vaccination policy that has been put in place to control Newcastle disease virus (NDV), the recent emergence of NDV genotype VII strains in Korea has led to significant economic losses in the poultry industry. We ssessed the ability of inactivated, oil-emulsion vaccines derived from La Sota or Ulster 2C NDV strains to protect chickens from challenge with Kr-005/00, which is a recently isolated Korean epizootic genotype VII strain. Six-week-old SPF chickens were vaccinated once and challenged three weeks later via the eye drop/intranasal route. All vaccinated birds were fully protected from disease, regardless of the vaccine strains used. All vaccinated and challenged groups showed significant sero-conversion 14 days after challenge. However, some vaccinated birds, despite being protected from disease, shed the challenge virus from their oro-pharynx and cloaca, albeit at significantly lower titers than the unvaccinated challenged control birds. The virological, serological, and epidemiological significance of our observations with regard to NDV disease eradication is discussed.
