Quality analysis of some drugs against tuberculosis an in vitro study
- VernacularTitle:Сүрьеэгийн эсрэг үйлчилгээтэй зарим эмийн in vitro орчинд хийсэн чанарын судалгааны үр дүн
- Author:
Nomintsetseg D
1
;
Badral D
1
Author Information
1. National Reference Laboratory, Mongolian University of Pharmaceutical Sciences
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
isoniazid;
pyrazinamide;
ethambutol;
rifampicin
- From:
Mongolian Pharmacy and Pharmacology
2022;20(1):57-62
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:According to the statistical data of 2019, 10 million people in 202 countries have been registered as tuberculosis cases, 1.6 million people has died around the world. In 2019, 4,089 new tuberculosis cases were determined, of which 265 died in Mongolia.
Purpose:The purpose of this study is analyze quality of some drugs used in the treatment of certain groups of tuberculosis in accordance with international standards.
Materials and methods:Isoniazid 300 mg, Rifampicin 150 mg, Pyrazinamide 400 mg and Ethambutol 400 mg, which are commonly used in Mongolia, were analyzed according to the pharmacopoeia methods of United States, Chinese and British.
Results:Appearance - Complies with the requirements of the certificate for sensory examination. Identification - It was determined by an infrared spectrophotometry. Average weight - Isoniazid
547.5 mg, Rifampicin 277.6 mg, Pyrazinamide 640.8 mg, Etambutol 399.6 mg. DisintegrationIsoniazid decomposes in 2.5 minutes, Pyrazinamide decomposes in 4.6 minutes, Etambutol decomposes in 8.5 minutes. Friability – Isoniazid - 0.4%, Pyrazinamide 10.4%, Hardness – Isoniazid 0.4%, Pyrazinamide is - 49.7 N, Dissolution – Isoniazid not less than - 95.7%, Rifampicin - 78.7%, Pyrazinamide - 95.7%, Assay - Etambutol is - 399.6 mg, Rifampicin is 139.94 mg, Isoniazid is - 293.6 mg Pyrazinamide - 492.5 mg complied with the standard requirements.
Conclusion:Analysis of tuberculosis drugs quality by pharmacopoeia methods including its appearance, identification, average weight, friability, hardness, disintegration, dissolution and assay, the isoniazid 300 mg tablets are complied with the United States pharmacopoeia, Rifampicin 150 mg tablets met British pharmacopoeia, and Ethambutol 400 mg tablets are complied with Chinese pharmacopoeia. Pyrazinamide 400 mg tablets did not complies the friability requirements of the United States Pharmacopoeia and also satisfied with the other requirements.
- Full text:MPPJ-2022-20(1)-57-62.pdf
