Some results of studies of “Монгол хунчир” injection
- VernacularTitle:“Монгол хунчир” тарилгын эмийн судалгааны зарим үр дүнгээс
- Author:
Tsendbadam B
1
;
Lkhaasuren R
2
;
Battulga B
2
;
Baljinnyam I
1
;
Tsetsegmaa S
2
;
Khurelbaatar L
3
;
Munkhtsetseg R
1
Author Information
1. Tsombo pharma Co., LTD
2. Drug Research Institute
3. Monos Group
- Publication Type:Journal Article
- Keywords:
Injection;
calicosin-7-o-β-d-glycosides;
Astragalus mongholicus
- From:
Mongolian Pharmacy and Pharmacology
2021;19(2):93-99
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:Astragalus is the largest member of the Fabaceae family of about 3,000 species on all continents except Australia, and the Astragalus mongholicus Bunge and the Astragalus membranaceus (Fisch.) Bge are studied and widely used. Astragalus contains polysaccharides, saponins, flavonoids, amino acids and trace elements, so it has a variety of pharmacological effects and is active in supporting the immune system and protecting the liver, heart and kidneys.
Objectives:A joint research team of the “Tsombo Pharm” Co., LTD and the Drug research Institute is conducting an experiment to produce an injectable solution from Astragalus mongholicus Bunge. The aim is to expand these previous studies to determine the main parameters of the “Монгол хунчир” injection drug technology.
Methods:The quality of the injection was assessed by the following parameters. These include: appearance, color of the injection solution, mechanical mixture sensing method, solution filling volume method, solution environment potentiometry method, solution clarity comparison method, insoluble particle size microscopy method, heavy metal mixture atomic absorption spectroscopy method and calicosine-7-o-β-d-glycoside content was determined by HPLC.
Results:According to the results of the study, the injectable drug was weak yellow, clear, free of mechanical impurities and heavy metal content, filling 2 ± 0.001 ml, pH 6.5, insoluble particle size greater than 10 μm, 3 particles per 1 ml, small particles larger than 25 μm were present in 1 ml. Calicosin-7-o-β-d-glycosides were identified in the “Монгол хунчир” injection as having the same standard and sample peak times, with the standard substance being detected at 9.003 minutes and the sample solution at 9.016 minutes (Picture 1, 2). In addition, the injection sample contained 0.0477 ± 0.0021 mg / g of calicosin-7-o-β-d-glycoside, and 0.0451-0.0551 mg / g was considered appropriate for further standardization.
Conclusions:The “Монгол хунчир” injection meets the general requirements for injection in accordance with the Mongolian National Pharmacopeia 2011. This shows that the technological parameters developed by our research team are appropriate.
- Full text:MPPJ-2021-19(2)-93-99.pdf
