Effects of Srog dzin-5 prescription on animal models of depressive disorders
- VernacularTitle:Амьтанд үүсгэсэн сэтгэл гутралын эмгэг загварт Амь баригч-5 жорын үзүүлэх нөлөө
- Author:
Altantuya Ts
1
;
Tsetsegmaa S
2
;
Bold Sh
3
Author Information
1. Mongolian University of Pharmaceutical Sciences
2. Institute of Pharmacology
3. Mongolian Academy of Sciences
- Publication Type:Journal Article
- From:
Mongolian Pharmacy and Pharmacology
2020;17(2):71-78
- CountryMongolia
- Language:Mongolian
-
Abstract:
Abstract:Ngo mtshar dga’ ston gter mdzod” by gelong (Fully ordained monk, Tib. དགེ་སློང་) Choijamts is one of the important medical books of traditional medicine. From this book, we found the Srog dzin-5 prescription and the purpose of the study is to determine acute and chronic toxicity of the prescription, and to identify its effect on animal models of depressive disorders.
Methods:
1. The study was conducted using quantitative research method by experimental research model.
2. Determination of acute and chronic toxicity.
3. Chronic Unpredictable Mild Stress (CUMS) Procedure.
Conclusion:
1. Srog dzin-5 prescription (LD50 = 25.8 (24-29) g/kg) has been shown to be non-toxic according to the generally accepted classification of K.Sidorov and B.Berezovskaya. When conducting histological studies, it was found that the surface of the liver, kidneys and adrenals is smooth. Color, shape and size of organs are normal.
2. In the model of chronic stress-induced depression, the Srog dzin-5 prescription increases physical activity, reduce tears, prevent anxiety and weight loss.
- Full text:MPPJ-2020-17(2)-71-78.pdf
