Advances in Lipotoxicity and Pancreatic β Cells Apoptosis (review)
- VernacularTitle:脂毒性与胰岛β细胞凋亡研究进展
- Author:
Yi ZHANG
;
Lin LIU
;
Jian-li GUO
;
Changshan LIU
- Publication Type:Journal Article
- Keywords:
type 2 diabetes, abnormal lipid metabolism, apoptosis, β cell
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(8):704-705
- CountryChina
- Language:Chinese
-
Abstract:
Both dysfunction of pancreatic β cells and β cells apoptosis were important factors contributing to type 2 diabetes. Abnormal glucose and lipid metabolism all existed in type 2 diabetes .With the study further progressing, more and more attention were paid to pancreatic β cells apoptosis accelerated by abnormal lipid metabolism. The literature about β cells injury by lipotoxicity, apoptosis induced factors accompanied by free fatty acids, and relevant mechanism was reviewed in this article.
