Stabilization of amoxicillin serum concentration by developing red blood cell-based drug delivery system
- VernacularTitle:Цусны улаан эсэд суурилсан эм зөөвөрлөх бүрдлээр цусны ийлдсэндэх амоксициллиний тунг тогтвортой барих нь
- Author:
Altansukh Ts
1
;
Tserendolgor B
2
Author Information
1. Mongolian National University of Medical Sciences
2. Mongolian University of Pharmaceutical Sciences
- Publication Type:Journal Article
- Keywords:
Drug delivery system;
red blood cell;
antibiotic
- From:
Mongolian Pharmacy and Pharmacology
2020;17(2):12-17
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:Many studies have been intensively conducted in the field of pharmaceutical
engineering to improve the drug efficiency by developing effective drug delivery systems. In
recent years, it has been reported that the concentration of amoxicillin in blood and stomach
after administration is not stable thereby decreasing its therapeutic efficacy. In the current,
we aimed to develop a red blood cell-based drug delivery system to maintain the amoxicillin
serum concentration.
Method:Erythrocyte swelling technology was used to prepare amoxicillin-loaded red blood
cells. After that, the shape, drug content, entrapment efficiency, hemolysis, drug release rate
and antibacterial effect were thoroughly investigated.
Results:Developed drug delivery system was round in shape. The drug content and entrapment efficiency were 33% and 62%, respectively. The drug release rate was evaluated
around 2.03%. Furthermore, the amoxicillin-loaded red blood cells were an effective agent
against E.coli while it wasn’t effective against S.aureus.
Conclusion:The results indicated that the red blood cell-based technology could stabilize
the amoxicillin serum concentration.
- Full text:MPPJ-2020-17(2)-12-17.pdf
