Adult Neurogenesis and Its Application in Ischemic Brain Injury Therapy (review)
- VernacularTitle:成年神经发生及其在缺血性脑损伤治疗中的应用前景
- Author:
Rui-qin YAO
;
Lin LI
- Publication Type:Journal Article
- Keywords:
neurogenesis, cerebral ischemia, neural stem cell, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(8):656-658
- CountryChina
- Language:Chinese
-
Abstract:
Recent evidence has shown that neurogenesis occurs throughout adulthood, and neural stem cells reside in the adult central nervous system (CNS) in mammals. Experimental stroke in adult mammals increases neurogenesis from neural stem cells or progenitor cells located in the dentate subgranular zone and the subventricular zone lining the lateral ventricle. New neurons can migrate to the areas of damage regions and express morphological markers characteristic of died neurons. These findings bring hope for self-repair after brain injury. The author of this paper reviewed the adult neurogenesis and its regulation in vivo, and described evidence for stroke-induced neurogenesis and neuronal replacement in the adult, and discussed the future research directions about neurogenesis after stroke and other brain injuries.
