Experimental Study of Schwann Cells Transplanted into Cerebral Hemorrhage Area of Rats
- VernacularTitle:大鼠脑出血移植施万细胞的实验研究
- Author:
Shao-dong ZHANG
;
Jun-hua Ll
;
Hong WAN
- Publication Type:Journal Article
- Keywords:
Schwann cells, myelin basic protein (MBP), growth associated protein-43 (GAP-43), rat
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(8):647-648
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of Schwann cells (SCs) transplanted into cerebral hemorrhage area on never restore in rat.MethodsSCs were expended and labeled with 5'-Bromodexyuridine (BrdU) in vitro, then transplanted into cerebral hemorrhage area of model rat. Double immunohistochemistry staining was used to detect the expression of BrdU/myelin basic protein (MBP) and BrdU/growth associated protein-43 (GAP-43) respectively.ResultsBrdU/MBP positive cells could be seen one week after transplantation and up to 13 weeks. GAP-43 positive cells appeared in 12 weeks and 13 weeks, which was more in Hippocamp.ConclusionGrafted SCs can participate in remyelination and promoter nerve restore.
