Present situation and prospect of development and vaccination of acellular pertussis vaccine
10.13200/j.cnki.cjb.003821
- VernacularTitle:无细胞百日咳疫苗研发与接种现状及前景
- Author:
CUI Le-le
- Publication Type:Journal Article
- Keywords:
Pertussis;
Acellular pertussis vaccine(aPVs);
Antigens;
Immunization;
Immune response
- From:
Chinese Journal of Biologicals
2023;36(2):235-
- CountryChina
- Language:Chinese
-
Abstract:
Whooping cough(pertussis)is a highly contagious respiratory disease,which mainly affects infants and young children.Vaccination is an effective measure to prevent pertussis infection.Due to the fewer side effects,acellular pertussis vaccines(aPVs)have replaced whole-cell pertussis vaccine(wPVs)in many countries.Despite vaccination coverage is high,the short immunity induced by aPVs is considered to be significant reason for the re-emergence of pertussis.For improving pertussis vaccine,genetically detoxified vaccine and live attenuated vaccine have showed obvious clinical results and other strategies including using novel adjuvants in aPVs,increasing antigen or packaging aPVs with nanoparticles also have good prospects.This paper reviews the antigen composition and protective effects of aPVs,vaccination programs in different countries,potential candidate components of pertussis vaccine and new strategies for prevention of pertussis.
