The role of CD28, CD40, CD45 RO and immunoglobulin G(FcyRI, FcyRII) in expression of T and B cells in mice
- VernacularTitle:Хулганы Т ба В эсийн нийлэгжилтэнд CD28, CD40, CD45RO болон иммуноглобулин G(FcyRI, FcyRII)-ний үүрэг
- Author:
Davaasambuu T
1
;
Choijamts G
1
;
Bayanmunkh A
1
;
Lkhagva L
1
;
Khurelbaatar L
2
Author Information
1. Drug Research Institute
2. Monos Group
- Publication Type:Journal Article
- Keywords:
T lymphocyte;
B lymphocyte;
Azathioprine;
Immunodeficiency;
Immunoglobulin;
phagocyte
- From:
Mongolian Pharmacy and Pharmacology
2019;14(1):24-28
- CountryMongolia
- Language:Mongolian
-
Abstract:
Purpose:In generally, T cell activation evaluates by CD4 +, CD8 +, B cell immunoglobulin's (IgG, IgM,
IgA) in Azathioprine caused secondary immunodeficiency in serum. May it does not make clearly
interpret for regulation of cell-mediated and humoral immune response using interaction T and B
cells. In this review, we discuss the multifaceted roles of cytokines as enhancers and expression of
B and T cell.
Cell-mediated Immunity and Humoral Immunity:Based on the type of immunodeficiency, the types of defects can vary. While some bacterial
infections may be a key feature of B cell and T cell defects are feature of combined T and B cell
immunodeficiency. Also other defects can be cause of phagocytes cell and complement deficiency.
The present study provides evidence special cytokines which are involved to expression of T and B
cells that CD40, IgG, IgM, FcyRII (CD32) need to be define with B cell deficiency, CD40, CD45RO
define combined T and B cell deficiency and FcyRI (CD64), CD45RO define for phagocytes cell deficiency and CD4+, FcyRI (CD32), FcyRI (CD64) define for complement deficiency. In this review,
we have done pharmacological study of immunosuppressant injection which is with Mongolian
Astragalus Mongolicus Bge and determined CD28, CD40, CD64, and CD45 cytokines in the blood
serum of mice. It will be clarifying the immune system interaction between cell-mediated immunity
and humoral immune for T cells and B cell interactions.
- Full text:MPPJ-2019-14(1)-24-28.pdf
