Result of nephroprotective effect of aqueous extracts of Iris Tenuifolia Pall and Iris Lactea Pall
- VernacularTitle:Нарийн навчит цахилдаг (Iris Tenuifolia Pall) болон цагаалин цахилдаг (Iris Lactea Pall) ургамлуудын усан хандны бөөр хамгаалах үйлдлийг тогтоох судалгааны үр дүн
- Author:
Sosorburam B
1
;
Davaasambuu T
1
;
Oyunchimeg B
1
;
Bayanmunkh A
1
;
Choijamts G
1
;
Lkhagva L
1
;
Khurelbaatar L
2
Author Information
1. Drug Research Institute
2. Monos Group
- Publication Type:Journal Article
- Keywords:
Kanamycin;
Nephritis;
Iris Tenuifolia, Iris Lactea;
Rat;
Nephropathy
- From:
Mongolian Pharmacy and Pharmacology
2019;14(1):12-18
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Iris Tenuifolia and Iris Lactea known for its various medicinal properties are
also a natural antichloristic and a kidney protective as agent.
Goal:To evaluate the nephrite activity of aqueous extract of Iris Tenuifolia and Iris Lactea in
a rodent model of kanamycin induced nephrotoxicity.
Materials and Methods:In the experimental design, thirty-six Wistar rats were randomly isolated into four groups of one control and three experimental. Nephrotoxicity in rats induced by intramuscular injection of Kanamycin {250 mg/kg) daily for 5 days5. The doses of 25 mg/kg, 50 mg/kg, 75 mg/kg, 100 mg/kg of aqueous extract of Iris Lactea and dose of 25 mg/kg Iris Tenuifolia Pall were administrated by oral gavages for 14 consecutive days in rats. At 14 days for the rest of them, serum samples were collected for renal function biochemical tests (Creatinine, Creatinine Clearance, Urea UV and GFR-Glomerulus Filtration Rate).
Results:All statistical analyses were conducted with SPSS version 20.0 software (IBM,
Armork. NY). One-way ANOVA was used to assess statistical significance between experimental
groups and control group. Mean values of creatinine, creatinine clearance, urea UV and GFR levels
determined in the control and experimental groups. Kanamycin treatment caused nephrotoxicity
as evidenced by marked elevation in serum creatinine, creatinine clearance, GFR and urea UV,
Iris Tenuifolia 25 mg/kg blood serum creatinine (62.49±1.24 (38%), 56.38±1.41 (4.5% μmol/L), serum creatinine clearance (4.79±0.16 (45%), (5.80±0.36 (6%) ml/minute), serum GFR (191.6±6.58
(45%). (232±14.65 (5.9%) ml/minute), serum urea UV (8.64±0.63 (9.6%), (8.40±0.07 (20.23%), Iris
Lactea 75 mg/kg blood serum creatinine 68.92±4.08(31%), 58.87±1.95 (0.4% μmol/L), serum creatinine clearance (5.27±0.67(60%), (5.67±0.28(3.6%) ml/minute), serum GFR (210.9±26.78 (60%),
(226.8±11.28 (3.5%) ml/minute), serum urea UV (7.73±0.58 (19.14%), (7.48±0.35 (28.96%) respectively when compared to the control treated groups. Oral administration of Iris Lactea 75 mg/kg extract decreased the rise in these parameters in a dose dependent manner.
Conclusion:Our studies suggest that aqueous extract of Iris Lactea 75 mg/kg and Iris tenuifolia 25 mg/kg results are shown good effect for anti-inflammatory of renal.
- Full text:MPPJ-2019-14(1)-12-18.pdf
