Research progress on T cell glycolytic metabolism in oral lichen planus
- Author:
XING Wenmin
1
;
GE Xuejun
1
;
WU Shujuan
1
;
ZHANG Fang
1
Author Information
- Publication Type:Review
- Keywords: oral lichen planus / glycolysis / glucose transporter 1 / glyceraldehyde3-phosphate dehydrogenase / lactate dehydrogenase A / hypoxia inducible factor-1α / mammalian target of rapamycin / 2-deoxy-D-glucose / rapamycin
- From: Journal of Prevention and Treatment for Stomatological Diseases 2023;31(9):679-684
- CountryChina
- Language:Chinese
- Abstract: Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa. The pathogenesis of OLP is still unclear. Immune abnormalities mediated by T cells and related cytokines play a crucial role in the pathogenesis of OLP. In recent years, glycolytic metabolism-related transporters, enzymes and regulators, such as glucose transporter-1 (Glut1), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), lactate dehydrogenase A (LDHA), mammalian target of rapamycin (mTOR) and hypoxia inducible factor-1α (HIF-1a), have attracted an increasing amount of attention in OLP by regulating the proliferation and differentiation of T cells and the secretion of inflammatory factors. It has been shown that 2-deoxy-D-glucose (2-DG) or rapamycin (RAPA) inhibits the glycolytic metabolism of T cells and then inhibits OLP. This article reviews the research progress of glycolytic metabolism-related transporters, enzymes and regulatory factors in OLP in recent years.
- Full text:T细胞糖酵解代谢在口腔扁平苔藓中的研究进展.pdf
