Research progress of broadly neutralizing antibodies against human immunodeficiency virus
10.13200/j.cnki.cjb.003826
- VernacularTitle:人免疫缺陷病毒广谱中和抗体的研究进展
- Author:
ZHANG Hui
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Broadly neutralizing antibodies;
Acquiredimmune deficiency syndrome(AIDS)
- From:
Chinese Journal of Biologicals
2023;36(2):217-
- CountryChina
- Language:Chinese
-
Abstract:
Acquired immune deficiency syndrome(AIDS)is a global public health issue,which has a major impact on human life and health.As the main pathogen of AIDS,human immunodeficiency virus type 1(HIV-1)has high variability and latent characteristics,there are no available vaccines and drugs to prevent and cure AIDS.The broadly neutralizing antibodies(bNAbs)against HIV-1 can induce effective immune response to HIV-1 infection in vivo,and neutralize different types of strains at the same time,which have great application potential in preventing HIV-1 infection and controlling the process of AIDS.In this paper,the production and acquisition,classification and characteristics as well as application of HIV-1bNAbs are reviewed so as to provide a reference for the subsequent research on HIV-1 vaccine and development of antibody drugs.
