Toxicity study of three roots granule medicine
- Author:
Enkhsuren E
1
;
Munkhtsetseg M
1
;
Jin Wen Jie
1
;
Chen Hong Mei
1
;
Wang Xiu Lan
1
Author Information
1. College of Mongolian Medicine and Pharmacology, Inner Mongolian University for the Nationalities
- Publication Type:Journal Article
- Keywords:
San Gen granule medicine;
acute toxicity test;
Genotoxicity test
- From:
Mongolian Pharmacy and Pharmacology
2018;12(1):45-50
- CountryMongolia
- Language:English
-
Abstract:
Purpose:To study the effect of Three roots granule medicine with compound medicines
ingredient of Asparagus cohinchinensis, Polygonatum odoratum and Polygonatum sibiricum on
acute toxicity test and genotoxicity tests.
Methods:In toxicity study of Three roots granule medicine, by acute toxicity test were observed
general status of animals, body weight changes, signs of poisoning and death for 14 day and
determined the maximum tolerated dose, by Ames test, mouse bone marrow polychromatic
erythrocyte micronucleus test and mouse sperm deformity test were determined genotoxicity
effect. The data were analyzed through SPSS 19.0.
Results and Conclusions:In the result of toxicity study, three roots granule medicine was
MTD>15g/kg, no acute toxic activity, did not induce mutagenic effect in Ames test and was negative
in mouse bone marrow polychromatic erythrocyte micronucleus test and mouse sperm deformity
test. Three roots granule medicine has no acute toxicity effect, no genotoxicity effect and safety.
We as regard as in future can continuously study to the other pharmacology study of three roots
granule medicine.
- Full text:MPPJ-2018-12(1)-45-50.pdf
