Laxative effect of Rheum undulatum L. Extract on loperamide induced constipation in wistar rats
- VernacularTitle:Харханд лоперамидаар үүсгэсэн өтгөн хаталтын үед долгионтсон гишүүнэ (Rheum undulatum)-ий хандны туулгах нөлөөг судалсан дүн
- Author:
Sosorburam B
1
;
Davaasambuu T
1
;
Oyunchimeg B
1
;
Badamtsetseg S
1
;
Lkhagva L
1
;
Khurelbaatar L
2
Author Information
1. Drug research institute
2. Monos Group
- Publication Type:Journal Article
- Keywords:
Laxative;
gastro intestinal motility;
loperamide;
constipated
- From:
Mongolian Pharmacy and Pharmacology
2018;12(1):38-41
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:Constipation is highly prevalent, often chronic gastrointestinal disorder that affects
adults. The treatment with classic drugs did not cut, in one hand with the inadequate relief of bloating
and other symptoms, and with the luck of efficacy in relieving constipation. Therefore, the search
for novel safe laxative drugs seems, inevitable. Rheum undulatum L. was traditionally used in
constipation, thus we have attempted to evaluate the laxative effect of Rheum undulatum L.
Purpose:The laxative effect of Rheum undulatum L. was evaluated against loperamide
induced constipated rats.
Methodology:Fifteen male normal rats were used in this study. Fifteen male constipated wistar
albino rats weighing 180-250 g were also used for the study and randomized into three groups
(n=5) in each of the experiments. Constipated control group rats oral administrated distilled water.
Constipated rats (treatment groups) were treated with 4.1 mg/kg dose body weight /day of the
preparation for one day and also Laxing a standard drug was used for the reference group. The
fecal weight, the fecal humidity laxative activity were monitored in experimental rats.
Results:Constipation was successfully induced in the rats by loperamide as seen in the
elevated fecal properties compared to the control rats. The Rheum undulatum L. compounds
preparation administered orally produced significant laxative activity and reduced loperamide
induced constipation in dose dependent manner as seen in the increase of fecal output. The
same doses of the Rheum undulatum L. compounds preparation produced a significant increase
(P<0.05) fecal weight, the faeces humidity. The effect of the compounds preparation compares
favourably well with Laxing, a standard laxative drug.
Conclusion:The results of this study justify the use of Rheum undulatum L. compounds
preparation as a laxative in traditional medicine. The produced significantly increase in fecal output
of rats and the stimulation of gastrointestinal motility.
- Full text:MPPJ-2018-12(1)-38-41.pdf
