Comparatively study of the effect of immune system on three roots talh and granule
- VernacularTitle:Монгол эм гурван үндэсийн талх эм болон мөхлөг эмийн дархлаа тогтолцоонд нөлөөлөх үйлдлийг харьцуулан судлах нь
- Author:
Munkhtsteseg M
1
;
Enkhsuren E
2
;
Wang Xiu Lan
Author Information
1. College of Mongolian Medicine and Pharmacology, Inner Mongolian University for the Nationalities
2. Mongolian University of Pharmaceutical Sciences
- Publication Type:Journal Article
- From:
Mongolian Pharmacy and Pharmacology
2018;12(1):20-24
- CountryMongolia
- Language:Mongolian
-
Abstract:
Abstract:To comparatively study the effect of three roots talh(pulvis compositus) medicine and three
roots granule medicine in the immune system.
Materials and Methods:A total number of 32 healthy Wistar male rats weighing 180-220 grams
were taken and equally divided into four groups: healthy group; small dose (0.85g/kg) of three
roots talh medicine group(TRSD); high dose (1.7g/kg) of three roots talh medicine group(TRHD)
and three roots granule medicine group at dose 1.3g / kg(TRGM). Medicine was given once every
day for 42 days. At the end of the study, spleen index and thymus index were calculated and
IL-2, IL-6, TNF-α, iNOS, NO levels in blood plasma and spleen using ELISA(Magellan 7.2) was
determined and compared with healthy group.
Result:There was no statistically significant increase in spleen index and thymus index between
the healthy group and medicine groups(p>0.05). In blood plasma, there was no statistically
significant difference in IL-2, IL-6, TNF-α, iNOS and NO between healthy and medicine groups
(P> 0.05).
In spleen, there was significant increased in IL-2 in the high dose three roots talh medicine
group in compare with healthy group (p<0.05). Similarly, IL-2, IL-6 and TNF-α was significantly
increased in three roots granule medicine group in comapre with healthy group (P<0.05; P<0.05;
P>0.001 respectively). There was no significant difference in iNOS and NO between healthy and
medicine groups (p>0.05).
Conclusions:Three roots talh medicine and three roots granule medicine has active of immune
system and three roots granule medicine has more activates the immune system compared to the
three roots talh medicine.
- Full text:MPPJ-2018-12(1)-20-24.pdf
