Pharmacological study on the nephroprotective effects of Tribulus terrestris L.
- VernacularTitle:Зэлэн зангуу (tribulus terrestris L.)-ны бөөр хамгаалах үйлдлийн фармакологийн судалгаа
- Author:
Akhtolkhyn T
1
;
Chengzhi Ch
2
;
Boyang Y
2
Author Information
1. Department of pharmaceutical chemistry and pharmacognosy, Mongolian University of Pharmaceutical Sciences, Ulaanbaatar, Mongolia
2. China Pharmaceutical University, Nanjing, China
- Publication Type:Journal Article
- Keywords:
Tribulus terrestris L;
cisplatin;
nephroprotective
- From:
Mongolian Pharmacy and Pharmacology
2018;12(1):4-6
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:Tribulus terrestris L. (TTL) is an annual plant of the family Zygophyllaceae that
has been used for many diseases including urinary tract diseases. The fruits and roots of TTL
have been used as a folk medicine for thousands of years in Mongolia, China, Iraq, India, Sudan
and Pakistan. Numerous bioactive phytochemicals, such as saponins, flavonoids, alkaloids and
glycosides, have been isolated and identified from TTL that are responsible alone or in combination
for various pharmacological activities. However, to date, the nephroprotective effects of TTL on
cisplatin-induced animal models have not been investigated.
Purpose:The present work aimed to investigate the protective effects of different doses of
Tribulus terrestris L. (TTL) against cisplatin-induced nephrotoxicity in mice.
Materials and methods:The renal injury was modeled by intraperitoneal injection of cisplatin
for 5 consecutive days (5 mg/kg). Nephroprotection of TTL was investigated by oral administration
of different doses of TTL aqueous extract at a daily dose of 20 mg/kg and 40 mg/kg for 14
consecutive days, starting 7 days prior to cisplatin administration.
Results:We demonstrated that pretreatment with different doses of TTL aqueous extract
significantly reduced blood urea nitrogen (BUN) and serum creatinine (Cr) levels and
histophatological changes observed in cisplatin-administrated mice.
Conclusion:These data suggested that TTL might be a potential candidate for neoadjuvant
chemotherapy of cisplatin. The dose of TTL 40 mg/kg was the most effective.
- Full text:MPPJ-2018-12(1)-4-6.pdf
