Research progress about effective components of Astragali Radix in the intervention of diabetic retinopathy and its mechanism
- VernacularTitle:黄芪干预糖尿病视网膜病变的有效成分及其作用机制研究进展
- Author:
Ruicheng LIU
1
;
Ling KONG
1
;
Ye SUN
2
;
Xijun WANG
1
Author Information
1. Chinmedomics Research Center of National Administration of Traditional Chinese Medicine/Key Laboratory of Serum Pharmacochemistry of National Administration of Traditional Chinese Medicine/Chinese Medicinal Materials GAP Site，Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. State Key Laboratory of Dampness Syndrome of Chinese Medicine，the Second Affiliated Hospital of Guangzhou University of Chinese Medicine，Guangzhou 511400，China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
Astragali Radix;
active component;
mechanisms
- From:
China Pharmacy
2023;34(11):1404-1408
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy （DR） is a common complication of diabetes， which causes a great threat to the health of human vision. Recent studies have shown that saponins， polysaccharides and flavonoids in Astragali Radix regulate phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway， silent information regulator 1/nuclear factor erythroid 2-related factor 2 pathway， B-cell lymphoma-2 and other signaling pathways by acting on nuclear factor-κB， hypoxia-inducible factor-1α， glial fibrillary acidic protein， glutamine synthetase， aldose reductase， multiple miRNA and other related targets， so as to exert anti- inflammatory， anti-microangiopathy， anti-neurodegenerative disease and anti-apoptosis， and then achieve the purpose of treating DR.
