Progress in research methods or strategies of compatibility mechanism of traditional Chinese medicine prescriptions
- VernacularTitle:中药复方配伍机制研究方法/策略进展
- Author:
Lei ZI
1
,
2
;
Yanjuan LI
1
,
2
;
Yanqin LI
1
,
2
;
Tao WANG
1
,
2
;
Junjie HAO
1
,
2
;
Jie YU
1
,
2
;
Xingxin YANG
1
Author Information
1. College of Pharmaceutical Science，Yunnan University of Chinese Medicine，Kunming 650500，China
2. Yunnan Key Laboratory of Southern Medicine Utilization，Kunming 650500，China
- Publication Type:Journal Article
- Keywords:
prescription of traditional Chinese medicines;
compatibility mechanism;
pharmacodynamic substances;
research
- From:
China Pharmacy
2023;34(11):1393-1398
- CountryChina
- Language:Chinese
-
Abstract:
Compound formulas of traditional Chinese medicines （TCM）， also known as prescription in clinic， refers to a form of medication in which several TCMs are selectively combined according to the certain compatibility principles and the needs of patient’s condition， based on syndrome differentiation and treatment. At present， the methods and strategies for investigating the compatibility mechanisms of TCM prescriptions mainly focus on the following two aspects: analysis of pharmacological substances （including chemical composition analysis of TCM， ingredients of TCM analysis in blood， and pharmacokinetic analysis） and pharmacological signaling pathways analysis （involving network pharmacology analysis， signal pathway indicator detection， and metabolomics analysis）. In future research， the compatibility relationships of TCM prescriptions should be explored according to the principles of “Qiqing Hehe”，“ Shengjiang Fuchen”，“ Junchen Zuoshi”， and “Siqi Wuwei”. The regularity of TCM prescriptions compatibility should be shown in the change regularity of chemical components， pharmacokinetics， pharmacological pathways， and chemical compositions of various ratios of TCMs. Based on the insurance of holistic efficacy of TCM prescriptions， the underlying mechanisms of compatibility should be uncovered， which will provide references for the optimization of clinical applications of prescriptions and new directions for the creation of innovative TCM prescriptions.
