Study on relation between phases of open heart surgery with cardiopulmonary bypass and coagulation parameters
- VernacularTitle:Цусны зохиомол эргэлтийн нөхцөлтэй зүрхний “нээлттэй” мэс заслын үеүдийг цусны бүлэгнэлтийн үзүүлэлтүүдтэй холбон судлах нь
- Author:
Manaljav G
1
,
2
;
Tuvjargal Ch
3
,
4
;
Zevgee T
1
;
Purevsuren D
4
;
Sodgerel B
4
;
Baasanjav N
3
Author Information
1. Etugen Univeristy
2. Emergency Medical Service Center
3. State Third Central Hospital named after Shastin P.N.
4. Institute of Medical Sciences
- Publication Type:Journal Article
- From:Mongolian Medical Sciences
2017;179(1):19-24
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Cardiac surgery with cardiopulmonary bypass is grown rapidly in last years. The
application of cardiopulmonary bypass using a heart-lung machine to perform open heart surgery
is known to be associated with numerous pathophysiologic changes including injury of cellular
components as erythrocyte, platelets, coagulopathy, and fibrinolysis.
Objectives:Our study objective is to study on relation of open heart surgery phases and blood
coagulation parameters.
Materials and Methods:Blood samples from 49 patients (28 females and 21 males, aged 18-
63 years) who underwent open heart surgery with cardiopulnonary bypass (CPB) were collected
before and at several time points during, after surgery and analyzed for coagulation parameters
at Shastin Third Central Hospital.
Results:To compare long continued cardiopulmonary bypass (over 1 h) surgery with less 1
h groups there prothrombin time was found 18.8±5.9 sec, international normalized ratio (INR)
2.09±0.9 sec prolonged (p<0.001) in 7 days after surgery. All coagulation parameters were
decreased significantly (p<0.001) in during extracorporeal circulation and after 1 h declamping
than preoperative level and reached near normal value in 48 h after surgery. Our results have
referred to platelet counts reduction to about 53% in during surgery, 46.8% in 48 h after surgery
of the preoperative level 237.4±57.1 with final return to normal levels 228.9±78.6 within 7 days.
Conclusions:
1. The cardiopulmonary bypass time and patient age in relation to open heart surgery type there
were significant difference (p <0.01).
2. The coagulation parameters have revealed significant changes (p <0.01) in relation
cardiopulmonary bypass time.
3. All coagulation parameters were decreased significantly (p<0.001) in during extracorporeal
circulation and after 1 h decamping than preoperative level and reached near normal value in
48 h after surgery.
4. There was direct and less correlation between platelet level and CPB time (r=0.37, p<0.001).
- Full text:2017-179(1)-19-24.pdf
