Hormonal and lipid profile in infertility women with polycystic ovary syndrome
- VernacularTitle:Өндгөвч уйланхайжих хамшинжийн шалтгаант үргүйдэлтэй эмэгтэйчүүдийн даавар, өөх тосны солилцооны үзүүлэлтийг тодорхойлсон нь
- Author:
Algirmaa N
1
,
2
;
Amarjargal O
2
;
Battulga G
2
;
Altaisaikhan Kh
1
;
Munkhtsetseg D
1
;
Bolorchimeg B
1
Author Information
1. Mongolian National University of Medical Sciences
2. National Center for Maternal and Child Health of Mongolia
- Publication Type:Journal Article
- Keywords:
Anti-Mullerian hormon;
metabolic syndrome;
infertility women;
Mongolia Polycystic;
ovarian syndrome
- From:Mongolian Medical Sciences
2020;194(4):17-24
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:PCOS prevalence is 5-10 percent among reproductive age women in worldwide. It is caused by
imbalance of sex hormones which ultimately leads to menstrual irregularities, infertility, anovulation
and other metabolic disturbances. Most women with chronic anovulation is caused by polycystic
ovary syndrome [PCOS] The Rotterdam criteria is useful diagnostic tool for PCOS. In Mongolia
there is almost no study on PCOS related infertility and there are increasing trend infertility among
reproductive aged women with PCOS, lead us to conduct the study.
Objective:The aim of this study was to estimate incidence of PCOS and to study clinical and biochemical
characteristics of PCOS among infertility women.
Material and Methods:We used the cross-sectional and case control study designs. Total 1334 infertility women enrolled
in this study. The study was conducted after approval from the Ethical and research review board of
the hospital, and written informed consent was taken from all the women. Among 114 women with
PCOS were found by Rotterdam’s criteria at the Infertility and reproductive department, National
Center for Maternal and Child Health, between December, 2018 - 2019. Total of 43 females with
PCOS were screened among 1334 infertile women. All parameters were assessed either with ELISA
in 43 infertile PCOS women and 17 age matched apparently healthy controls diagnosed according
to Rotterdam consensus. IDF diagnostic criteria for MS was used. The PCOS patients divided into
following groups: (1) with MS ( n=42) and (2) without MS (n=72).
Results:The main age, body mass index (BMI), and duration of infertility were 28.7±4.1 years, 27.3±5.2 kg/
m² and 4.4±3.1y, respectively. Among patients 57.9% of them have oligomenorrhea, 22.8% with
amenorrhea, primary infertility 57.0% and 51.9% with hirsutism and acne 50.8%. As a result of
hormone assays were LH 9.3±3.5mIU/ml, LH/FSH 1.6 ±0.83 [0.1-3.6], AMH 6.1ng/ml ±3.6 /2.9-21.0/.
The prevalence of MS was 36.8%. The variables including age (30.9±4.9), body mass (75.9±11.6kg)
and also some metabolic parameters which is hypertension (133.6/88.4±13.6 mm Hg), WC (94.1±8.6
cm) and high triglyceride (1.8±1.0 mmol/l) were observed in MS group compared to without MS group.
Conclusion:Among 1334 women with infertility, the incidence of PCOS 8.7% (116), close to the prevalence in
other countries. Considering the diagnose was confirmed of three criteria by the Rotterdam criteria.
We found out that the prevalence of metabolic syndrome was 35.3% among infertility women with
PCOS. Age, BMI, WC, amenorrhea, acne and acanthosis nigricans, were highly related to metabolic
syndrome.
- Full text:2020-194(4)-17-24.pdf
