Effect of Spinal Cord Injury and Training on Expression of Myosin Heavy Chain of Skeletal Muscle (review)
- VernacularTitle:脊髓损伤肌萎缩肌球蛋白重链可塑性与训练的影响
- Author:
Xiaohua FAN
;
Shurong JI
;
Hongjun ZHOU
- Publication Type:Journal Article
- Keywords:
spinal cord injury, muscle atrophy, myosin heavy chain, training, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(6):508-510
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal muscle contractile properties are determined by their myosin heavy chain (MHC) expression profiles partly. Spinal cord injury induced the adaptation change in MHC isoform mRNAs and protein expression of skeletal muscle below the injured level, leading to the increased expression of fast and decreased expression of slow MHC isoforms. The adaptations in the MHC-mRNAs preceded the changes in proteins. The degree and velocity of MHC isoform adaptation were dependent on differenrt muscle and animal species. Short-term training could not induce the significant change of the transformation of MHC isoform, whereas long-term stepping training which emphasized load bearing could attenuate the MHC shift from slow toward faster isoforms.
