Factors Related with Therapeutic Effect and Prognosis of Postoperative Radiotherapy for Nasal and Paranasal Sinuses Carcinoma
- VernacularTitle:影响鼻腔副鼻窦恶性肿瘤术后放疗效果与预后因素分析
- Author:
Gao-qiang QI
;
Ying-xuan WANG
;
Shu-xiang CUI
;
Xiangkun DAI
- Publication Type:Journal Article
- Keywords:
nasal and paranasal sinuses carcinoma, postoperative radiotherapy, side effect
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(6):535-537
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the factors related with curative effect and prognosis of postoperative radiotherapy for nasal and paranasal sinuses carcinoma.MethodsThe data of 95 patients with nasal and paranasal sinuses carcinoma and received postoperative radiotherapy were reviewed retrospectively. Kaplan-Meier method was used to analyze the survival, Logrank test used to compare the differences between different groups. Multivariate analysis was performed by Cox proportional hazard model.ResultsThe overall 1, 3, 5, 10-year survival rates of 95 patients were 84.2%, 50.5%, 44.2% and 20% respectively. Univariate analysis showed that sex, age, operative modality and tumor dose were not related with survival. Histological and clinical stages were related with survival. Multivariate analysis indicated that histological and clinical stages were independent prognostic factors. The follow-up results showed that visual disturbance, xerostomia, dysaudia were the major side effects.ConclusionPostoperative radiotherapy can improve therapeutic effect in the treatment of nasal and paranasal sinuses carcinoma, and histological and clinical stages are the independent prognostic factors effecting prognosis.
