Effect of Breviscapine on Rabbit's Cardiac Muscles after Ischemic Preconditioning
- VernacularTitle:灯盏花素对家兔缺血预适应心肌保护作用的影响
- Author:
Guo-an ZHAO
;
San-qiang ZHANG
;
Zhi-gang CHEN
;
Guotian YIN
;
Haiyan SUN
- Publication Type:Journal Article
- Keywords:
myocardial ischemic reperfusion, ischemic preconditioning, Breviscapine, nitrous oxide, endothelin
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(6):467-468
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effect of the Breviscapine (Bre) on rabbit's cardiac muscles after ischemic preconditioning (IP).MethodsThe myocardial ischemic reperfusion model was made with 32 New Zealand white rabbits by silk thread passed around the left circumflex coronary artery and the apex. Model animals were randomly divided into four groups: myocardial ischemia-reperfusion (I/R) group, Bre+I/R group, IP group and Bre+IP group. The changes of the endothelin (ET), nitrous oxide (NO) and the enzymes of the cardiac muscle were measured, and the areas of myocardium infarction were analyzed.ResultsBre and IP could decrease the content of ET, the enzymes of the cardiac muscle and myocardial infarction area; increase the content of the NO. Bre+IP could strengthen the role of protecting the ischemic myocardial cells.ConclusionThe Bre can protect the ischemic cardiac muscle. The Bre+IP can strengthen the protective effect of the IP.
