Morbidity of Malignant Hyperthermia in Central Core Disease Patients Undergoing Orthopedics
- VernacularTitle:中央轴空病患者畸形矫正术中的恶性高热风险
- Author:
Shi-wen WU
;
Wei-ya MA
;
Sheng-yuan YU
;
Dingguo SHEN
- Publication Type:Journal Article
- Keywords:
central core disease, malignant hyperthermia, orthopedics
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(5):427-428
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the incidence of skeletal and/or articular malformations in central core disease (CCD) patients, and their risk of malignant hyperthermia (MH) in orthopedics. Methods28 unrelated patients with central core disease collected in the past 23 years were analyzed retrospectively. Results22 patients showed limb muscle weakness, while 6 patients didn't show any clinical symptom. Skeletal and/or articular malformations appeared in 21 patients, including joint contracture in 11, joint dislocation in 9, scoliosis in 12, lordosis in 5 and thoracic deformity in 1. 6 of the 10 patients could not endure orthopedic operation because of MH attack or dubitable MH attack. Calcium-induced calcium release (CICR) test performed on other 8 patients with MH family history or MH attack showed all those patients were MH susceptibilities. ConclusionSkeletal and/or articular malformations are common in CCD, as well as MH attack in orthopedics.
