Biocompatibility of Rapamycin-Batroxobin Eluting Stent in Porcine Coronary Artery
- VernacularTitle:雷帕霉素和巴曲酶复合药物涂层支架的生物相容性实验研究
- Author:
Dan CHEN
;
An-lin Lü
;
Wei ZHANG
;
Yuan YUAN
;
Fanrong DIAO
;
Junjie LI
- Publication Type:Journal Article
- Keywords:
stent, histompatibility, rapamycin, batroxobin
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(5):399-400
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo illustrate the biocompatibility of rapamycin-batroxobin eluting stent(RBES). MethodsStent made with rapamycin-batroxobin and polymer were implanted in the coronary artery of experimental group and the rapamycin with the polymer in the control group, which including 8 miniature pigs in each group. Coronary arteriographies were taken before, exactly after implanting the stent and before sacrificed the pigs. The whole blood cell counts, biochemical indexes, blood pressures, heart rates, body weights before implantation and sacrifice, together with the behavior states during the observation were analyzed. The coronary arteries of the implantation segment were observed under the scanning electron microscope and histologically. Lungs, stomachs, intestines, bowels, livers, kidneys and the ventricular walls which infused by the stents supported arteries were also observed histologically. ResultsBone marrow suppression, hemolysis, liver and kidney disfunction had not been found in the 2 groups. There was no significant difference in heart rate, blood pressure and body weight between 2 groups. Behavior was not influenced. All stents were implanted successfully. And there was no stenosis in coronary artery in both group during the 28-day period. There were no significant differences in endothelium square and the ratio of endothelium square to tunica media square. No definite inflammatory cell was found. There were no pathological damages related to RBES in lungs, stomachs, intestines, bowels, livers, kidneys and the ventricular walls infused by the stent supported arteries.ConclusionThe blood compatibility and histocompatibility were good after RBES were implanted in coronary arteries of miniature pigs.
