Correlation between the Promoter Polymorphism of Fibroblast Growth Factor 1 gene and Late-onset Alzheimer's Disease
- VernacularTitle:成纤维细胞生长因子1基因启动子多态性与晚发型阿尔茨海默病的相关性研究
- Author:
Yu-sen CHEN
;
Bin ZHAO
;
Zhi-en XU
;
Hidehisa yamagata
;
Tetsuro miki
- Publication Type:Journal Article
- Keywords:
late-onset Alzheimer's disease, fibroblast growth factor 1 (FGF-1) gene, promoter polymorphism, correlation
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(5):394-395
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the correlation between the promoter polymorphism of Fibroblast Growth Factor 1 (FGF-1) and late-onset Alzheimer's disease (LOAD). MethodsClinic pathological data from 206 autopsies were analyzed, including 100 autopsy-confirmed LOAD patients and 106 age-matched non-demented controls. PCR-RFLP (Restriction fragment length polymorphism) approach was used to determine the genotype of the promoter polymorphism of FGF-1 gene. ResultsThe genotyping frequencies of the promoter polymorphism (-1385 A/G) were AA 20 (10%), GA 89 (43%), GG 97 (47%), respectively. There was significant (P=0.027) difference of genotyping frequencies between the cases and controls; GG genotype was positively associated with LOAD (odds ratio=2.02, 95%CI:1.16～3.52). ConclusionThe promoter polymorphism (-1385 A/G) of FGF-1 gene was associated with LOAD.
