Comparison of Behavioral and Histological Changes between Pilocarpine-Induced Temporal Epilepsy Model and Pentylenetetrazole Kindling Absence Model in Rats
- VernacularTitle:颞叶癫痫模型和失神癫痫模型的行为学、组织学对比研究
- Author:
Ben-guo WANG
;
Wei-ping LIAO
;
Ai-hua LUO
;
Weiwen SUN
;
Tao SU
;
Yonghong YI
- Publication Type:Journal Article
- Keywords:
pilocarpine-induced epilepsy model, pentylenetetrazole kindling model, behavior, neuron loss, mossy fiber sprouting
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(5):391-393
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate and compare the behavioral changes, neuron loss of hippocampus and mossy fiber sprouting between pilocarpine-induced status epilepticus (SE) model and pentylenetetrazole (PTZ) kindling model in rats.MethodsAfter two different epilepsy models were made, Vedio was adopted to observe the behavioral changes. Nissl staining and Neo-timms' staining were separately used to observe and compare the neuron loss of hippocampus and mossy fiber sprouting in the dentate gyrus (DG) at different time points during epileptogenisis.ResultsNo recurrent spontaneous seizure, no neuron loss and no mossy fiber sprouting were found in PTZ kindling model; whereas obvious neuron loss was found in CA1, CA3 of hippocampus and hilus of DG, and mossy fiber sprouting were found in pilocarpine model in parallel with recurrent spontaneous seizures. ConclusionPTZ kindling model resembles absence epilepsy in human, while pilocarpine-induced status epilepticus model resembles chronic temporal epilepsy in human. Neuron loss and mossy fiber sprouting may play an important role in epileptogenisis. Pilocarpine-induced epilepsy model can be regarded as an ideal chronic temporal epilepsy model.
