Effect of Dendritic Cell Vaccine Coupled with Immune Adjuvant on the Inhibition of Murine Breast Carcinoma
- VernacularTitle:树突状细胞肿瘤疫苗联合免疫佐剂治疗小鼠乳腺癌的初步探讨
- Author:
Xin JIA
;
Rong LI
;
Ying-xin XU
;
Li LI
- Publication Type:Journal Article
- Keywords:
dendritic cell, immune adjuvant, breast carcinoma
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(5):381-382
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate whether immune adjuvant can enhance the immunity of dendritic cell vaccine against murine breast cancer. Methods4 groups of mice with tumor are injected saline, immume adjuvant, dendritic cell (DC) vaccine and DC vaccine coupled with immune vaccine, respectively. Tumor volume and weight are measured 21 d later.ResultsThe tumor size in the DC vaccine coupled with immune vaccine group was significantly small compared with control group (P=0.001) and the DC vaccine group (P=0.047).ConclusionImmune adjuvant can enhance the immunity of dendritic cell vaccine against murine breast cancer.
