Protective Effect of Curcumae on Acute Hepatic Injuried Mice Induced with Carbon Tetrachloride
- VernacularTitle:郁金抗四氯化碳致小鼠急性肝损伤的作用
- Author:
Fengying LAN
;
Jingchun HE
;
Ying ZHAO
;
Lijuan ZHAO
- Publication Type:Journal Article
- Keywords:
Curcumae, carbon tetrachloride, acute hepatic injury, mice
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(5):444-445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Curcumae on acute hepatic injuried mice.Methods The model mice of acute hepatic injury were established with intraperitoneal injecting 0.2% carbon tetrachloride (CCl4) 0.2 ml/10mg. 48 mice were randomized into 6 groups: model group, control group, Ganlixin group (25 mg/kg) and three treating groups of Curcumae which were administrated by gavage at the doses of 2.5 g/kg, 5 g/kg, 10 g/kg once everyday.7 d later, all mice were put to death. The liver index, the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) in serum, the activities of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in hepatic tissue were observed. Pathological change was observed under HE staining. Results Compared with the model group, Curcumae could decrease the liver index and the activities of ALT and AST in serum, MDA in hepatic tissue significantly (P<0.05), and increase the activities of SOD (P<0.05). The pathological changes were less in three treating groups than that of the models. Conclusion Curcumae can protect the liver from acute hepatic injuried induced with CCl4 in mice.
