Proliferative Activities of Hodgkin's Disease Cells Transfected with mtrⅡ Gene
- VernacularTitle:转染mtrⅡ基因后霍奇金病细胞增殖活性改变
- Author:
Xing WANG
;
Yudong LIN
;
Mingyuan WANG
;
Jianguo SHI
;
Dezhu WU
;
Yu WANG
;
Jingli DU
- Publication Type:Journal Article
- Keywords:
mtr Ⅱ gene, Hodgkin's disease, ki67 gene, proliferating cell nuclear antigen (PCNA)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(5):430-431
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the proliferative activities and significance of Hodgkin's disease cells which were transfected with mtr Ⅱ gene. Methods The ki67 and proliferating cell nuclear antigen (PCNA) expression in Hodgkin's disease cells transfected with mtr Ⅱ gene were determined with immunohistochemistry. Results The ki67 and PCNA expression in cells transfected with mtr Ⅱ gene was more than that of cells without mtrⅡ gene transfected (P<0.05). Conclusion The proliferative activities of Hodgkin's disease cells transfected with mtr Ⅱ gene increased obviously, which may be related to the progress of Hodgkin's disease.
