Effect of Percutaneous Laser Disc Decompression on Phospholipase A2 and Nerve Conduction Velocity in Rabbit with Prolapse of Intervertebral Disc
- VernacularTitle:经皮激光椎间盘减压术对兔椎间盘内磷脂酶A2及神经传导速度的影响
- Author:
Geng CUI
;
Dajiang REN
;
Jie LI
;
Peif TANG
;
Yutian LIANG
;
Sheng TAO
;
Qun ZHANG
;
Yizhu GUO
;
Xiangdang LIANG
;
Yan WANG
- Publication Type:Journal Article
- Keywords:
prolapse of intervertebral disc, nucleus pulposus, percutaneous laser disc decompression (PLDD), phospholipase A2 (PLA2), nerve conduction velocity (NCV)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(5):428-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of percutaneous laser disc decompression (PLDD) for treating prolapse of intervertebral disc. Methods 15 rabbits were divided into 3 groups randomly: sham group, model group with PLDD treatment, model group without PLDD treatment. The nerve conduction velocity (NCV) of L6 nerve root and the activity of phospholipase A2 (PLA2) in the intervertebral disc of L5-6 were determined 2 weeks after the initial surgery. Results NCV in the group with PLDD was significantly faster than that in the group without PLDD (P<0.001); NCV in the group without PLDD was significantly lower than that in the sham group (P<0.001). The activity of PLA2 in the group with PLDD was significantly lower than that in the group without PLDD (P<0.001); The activity of PLA2 in the group without PLDD was significantly higher than that in the sham group (P<0.001). Conclusion The activity of PLA2 in the herniated discs is higher than that in normal discs, which result in NCV falls remarkably. The PLDD can reduces chemical factors such as PLA2.
