Anticoagulant Activity of Hirulog in Rabbits in Vivo

VernacularTitle:国产水蛭肽对兔抗凝疗效观察
Author: Shan LI ; Luyue GAI
Publication Type:Journal Article
Keywords: hirulog, anticoagulant, rabbits
From: Chinese Journal of Rehabilitation Theory and Practice 2007;13(5):421-422
CountryChina
Language:Chinese
Abstract: Objective To study the anticoagulant activity of hirulog. Methods Rabbits blood samples were collected before and after injecting hirulog. Thrombin clot time (TT), prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured to investigate the dose-effect and time-effect relationship of hirulog and compared the efficacy with heparin. Results TT, PT and APTT of rabbits blood samples were prolonged remarkably by hirulog, and the action duration was about 60 min, that was similar to heparin. Conclusion Hirulog showed obvious anticoagulant effects with clear dose-effect relationship.