Effect of Shenlongtang on Learning and Memory of Aging Rats Induced with D-Glalactose
- VernacularTitle:参龙汤对D-半乳糖诱导衰老大鼠学习记忆功能的影响
- Author:
Liping CHEN
;
Zhitao HAN
;
Fawei WANG
;
Yi LIU
- Publication Type:Journal Article
- Keywords:
senescence, D-glalactose, Shenlongtang, Chinese medicine, learning, memory, superoxide dismutase (SOD), malodialdehyde (MDA), rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(5):419-420
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Shenlongtang on the function of learning and memory of aging rats induced with D-glalactose. Methods 40 Wistar rats were dividied into control group, model group, treating group 1 (large dosage), treating group 2 (medial dosage), treating group 3 (lower dosage). The aging models were induced with D-galactose. The memory function was tested with passageway water maze. The activity of superoxide dismutase (SOD) and content of malodialdehyde (MDA) was measured. Results In the D-galactose model rats, the swimming time was prolonged significantly, and the correct number was decreased significantly compared with normal group (P<0.05). After Six weeks treating with Shenlongtang, the swimming time significantly shortened and the correct number increased significantly in large dosage group compared with the model group (P<0.05). The activity of SOD increased and the content of MDA decreased in large dosage group compared with that in the model group (P<0.05).Conclusion Shenlongtang can improve the learning and memory function of aging rats induced with D-glalactose and resist lipid peroxide in brain tissue.
