Research progress on pathogenesis and molecular targeted therapy of radiation-induced lung injury
10.13491/j.issn.1004-714X.2021.03.023
- VernacularTitle:放射性肺损伤发病机制及分子靶向治疗研究进展
- Author:
Jiazhen CHEN
1
;
Yu WANG
1
;
Cunliang WANG
1
;
Xudong HU
1
Author Information
1. Department of Radiation Oncology, Shandong Cancer Hospital and Insitute, Shandong First Medical University and Shandong Academy of Medical Scinences, Ji'nan 250117 China.
- Publication Type:ReviewArticles
- Keywords:
Radiation-induced Lunginjury;
Pathogenesis;
Cytokines;
Molecular Targeted Therapy
- From:
Chinese Journal of Radiological Health
2021;30(3):377-380
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced lung injury is a common complication of radiotherapy for thoracic tumor, usually involves the radiation-induced pneumonitis at early stage and radiation-induced pulmonary fibrosis at late stage, which seriously affects the treatment and prognosis of patients. At present the common treatments for radiation-induced pulmonary fibrosis include anti-inflammatory therapy, glucocorticoid therapy, antioxidant therapy and so on. Recentlywith the further research of radiation-induced pulmonary fibrosis, more and more attention has attracted in molecular targeted therapy. Molecular targeted inhibitors is a new class of drugs for the treatment of radiation-induced lung injury, mainly targeting a variety of cytokines, signaling pathways, tyrosine kinase receptors and other targets. This article systematically reviews the pathogenesis and molecular targeted therapy of radiation-induced lung injury.
