Retrospective analysis of methicillin-resistant staphylococcus aureus skin and soft tissue infection among patients admitted at an academic university hospital from 2011 to 2015: A five-year review
10.35460/2546-1621.2019-0011
- Author:
Maria Angela M SANTOS
1
;
Arnelfa C PALIZA
1
Author Information
1. Department of Dermatology, University of Santo Tomas Hospital, Manila, Philippines
- Publication Type:Other Types
- Keywords:
CA-MRSA;
HA-MRSA;
Skin and soft tissue infection
- MeSH:
Methicillin-Resistant Staphylococcus aureus
- From:
Journal of Medicine University of Santo Tomas
2019;3(2):362-377
- CountryPhilippines
- Language:English
-
Abstract:
Introduction:The emergence of methicillin-resistant Staphylococcus aureus (MRSA) is a challenge
in the management of skin and soft tissue infections
(SSTIs).
Objective:To describe the epidemiology of MRSA
SSTIs among admitted patients at the University of
Santo Tomas Hospital (USTH).
Methods :This was a retrospective study of inpatients with MRSA SSTIs from 2011-2015. MRSA
infections were classii ed as community-associated
(CA-MRSA) and healthcare-associated (HA-MRSA).
Demographic characteristics, clinical proi le, comorbidities, complications, risk factors, antibiotic
susceptibility and resistance, treatment used, and
clinical outcome were determined.
Results:Out of the 331 inpatients with
Staphylococcus aureus SSTIs, 211 had MRSA with
a prevalence of 63.7%, 80.1% of MRSA were CAMRSA while 19.9% were HA-MRSA. The mean age
was 41.58 years with male predominance. The majority presented with abscess (62.9%), on the legs
(21.8%). The abscess was signii cantly associated
with CA-MRSA while infected wounds, previous
hospitalization, and surgery were correlated with
HA-MRSA. Growing resistance to ciprol oxacin, tetracycline, macrolides, co-trimoxazole, and clindamycin was noted. A low percentage of resistance to
vancomycin and linezolid was observed. Almost all
cases improved with appropriate antibiotic therapy
and 3.3% mortality
Conclusion:More than half of the patients with
Staphylococcus aureus SSTIs had MRSA. and were
mostly CA-MRSA and males. Abscess on the leg
was the common presentation and signii cantly associated with CA-MRSA. Infected wounds, previous
hospitalization, and surgery were associated with
HA-MRSA. There was high resistance of MRSA to ciprol oxacin and tetracycline while low resistance
to vancomycin and linezolid. Almost all improved
with appropriate treatment.
- Full text:1 JMUST 018.pdf
