Vitamin D serum levels in children with allergic and vasomotor rhinitis.
10.3345/kjp.2015.58.9.325
- Author:
Seung Jin LEE
1
;
Bong Hwa KANG
;
Bong Seok CHOI
Author Information
1. Depatment of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea. bschoi@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Allergic rhinitis;
Vitamin D;
Child;
Vasomotor rhinitis;
Immunoglobulin E
- MeSH:
Body Mass Index;
Calcium;
Child*;
Dermatitis, Atopic;
Eosinophil Cationic Protein;
Eosinophils;
Food Hypersensitivity;
Homeostasis;
Humans;
Immunoglobulin E;
Immunoglobulins;
Metabolism;
Phosphorus;
Rhinitis;
Rhinitis, Vasomotor*;
Seasons;
Skin;
Vitamin D*;
Vitamins*
- From:Korean Journal of Pediatrics
2015;58(9):325-329
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: In addition to regulating calcium and phosphorus homeostasis and bone metabolism, vitamin D is known as an immune modulator. Recently, there has been increased worldwide interest in the association between low levels of vitamin D and allergic diseases. The purpose of this study was to assess the relationship between serum vitamin D levels and allergic/vasomotor rhinitis (AR/VR) in children. METHODS: This study included 164 patients. The sample included 59 patients with AR, 42 patients with VR, and 63 controls. Their ages ranged from 0 to 16 years. We examined the levels of 25-hydroxyvitamin D, Immunoglobulin E, specific IgE, and eosinophil cationic protein; peripheral blood eosinophil count; and the results of a skin prick test. RESULTS: Serum 25-hydroxyvitamin D levels were 19.0+/-8.5 ng/mL in the AR group, 25.5+/-10.9 ng/mL in the VR group, and 26.9+/-10.7 ng/mL in the control group. After adjustment for body mass index and season at the time of blood sampling, vitamin D levels in the AR group were lower than those of the VR group (P=0.003) and control group (P<0.001). Vitamin D levels were inversely correlated with Immunoglobulin E levels (r=-0.317, P<0.001). AR patients with food allergy or atopic dermatitis did not have lower levels of 25-hydroxyvitamin D than AR patients without these diseases. CONCLUSION: This study demonstrates a possible relationship between vitamin D levels and allergic rhinitis in Korean children.
