Correlation of Glycosylated Hemoglobin And Oral Glucose Tolerance Test Results In Hyperinsulinemic Pre-Impaired Glucose Tolerance State Versus Normoinsulinemic-Normal OGTT
10.35460/2546-1621.2017-0042
- Author:
Pilar D TORRES-SALVADOR
1
;
Gelinemae G MALAZA
1
;
Leilani B MERCADO-ASIS
1
,
2
Author Information
1. Section of Endocrinology, Department of Internal Medicine, University of Santo Tomas Hospital, Manila, Philippines
2. Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines
- Publication Type:Journal Article
- Keywords:
HbA1C;
Normoinsulinemic
- MeSH:
Prediabetic State;
Hyperinsulinism
- From:
Journal of Medicine University of Santo Tomas
2018;2(1):155-159
- CountryPhilippines
- Language:English
-
Abstract:
Background :Prediabetes is an intermediate
stage prior to development of diabetes mellitus. Preimpaired glucose tolerance state represents an early
stage in the pathogenesis of diabetes wherein the
normal glucose is attained by compensated hyperinsulinemia. Glycosylated hemoglobin is used in diagnosis and monitoring of diabetes but has not been
explored in pre-IGT state. The objective of this study
is to compare the 2-hour blood glucose, 2-hour insulin level, and HbA1c between normoinsulinemic-normal OGTT and pre-IGT groups.
Methods:Conducted at University of Santo Tomas
Hospital, this was a retrospective analytical study of
high-risk individuals for evaluation of type 2 diabetes
from 2000-2011 and underwent 75-gm OGTT with
2-hour blood sugar and insulin determinations. The
2-hour glucose, insulin level and HbA1c in normoinsulinemic-normal OGTT were compared with the preIGT group using t-test. Correlation between the 2-hour
blood glucose and insulin level with the HbA1c was
done using Pearson correlation analysis. Statistical
signifi cance was considered for p-value of <0.05
Results:Second-hour blood glucose and insulin levels were signifi cantly higher in the pre-IGT
group as compared to the normoinsulinemic-normal OGTT group (128.60±18 and 89.29±68.82
vs. 90.68±26 and 17.40±8.15). The HbA1c of
the pre-IGT group was signifi cantly higher than the
normoinsulinemic-normal OGTT group (6.09±0.55
vs. 5.15±0.25, p-value <0.001). There was weak
positive correlation between the HbA1c and 2-hour
blood glucose levels between the two groups but not
with the insulin levels.
Conclusion:The pre-IGT groups have signifi cantly higher 2nd hour blood sugar, insulin and HbA1c levels. This suggests that indeed the metabolic abnormality must be addressed as early as the pre-IGT
stage.
- Full text:JMUST 6.pdf
