Low sustainability of weight loss among patients with non-alcoholic fatty liver disease
10.35460/2546-1621.2022-sp16
- Author:
Joseph Niño A ESPINO
1
;
Ann Margaret C NAVARROZA
1
;
Alvin Brian C VELASCO
1
;
Rommel ROMANO
1
;
Carmelita C DALUPANG
1
;
Frederick T DY
1
;
Stephen N WONG
1
Author Information
1. Section of Gastroenterology, University of Santo Tomas Hospital, Espana Blvd, Sampaloc, Manila, Philippines 1008
- Publication Type:Other Types
- Keywords:
Sustainability
- MeSH:
Non-alcoholic Fatty Liver Disease;
Weight Loss
- From:
Journal of Medicine University of Santo Tomas
2022;6(S1):126-133
- CountryPhilippines
- Language:English
-
Abstract:
Background:Weight loss, though difficult to attain and sustain over time, remains the cornerstone of non-alcoholic fatty liver disease (NAFLD) treatment. We aimed to describe weight changes among NAFLD patients.
Methods:This was a retrospective, cohort study of consecutively-identified NAFLD patients with >2 clinic visits from March2007–April2018. Weight changes from baseline were categorized into weight gain, weight loss, and no change. Baseline liver and metabolic biochemistries and non-invasive liver fibrosis tests were correlated with the final weight changes. Succeeding weight changes after the initial follow-up visits were used to determine sustainability of weight loss.
Results:Of the 240 patients included, 123 (51.2%), 93 (38.8%), and 24 (10%) had weight gain, weight loss, and no change, respectively. Only 12.5% had >5% weight loss. Duration of follow-up was significantly longer for patients with weight loss (p<0.001). None of the baseline demographic and laboratory data were associated with weight loss. Patients with weight loss also did not have significant changes to their biochemistries and non-invasive liver fibrosis tests compared to patients with weight gain/no change. Compared to patients with weight gain after the initial follow-up, where only 11.8% were able to lose weight on the final visit, 73.1% of patients who lost weight after the initial follow-up were able to sustain their weight loss on the final visit.
Conclusions:Weight loss is achieved in only a third of NAFLD patients. Although 73% of patients who lost weight initially were able to sustain it, patients who gained weight after the 1st follow-up were unlikely to lose weight on further follow-up.
- Full text:JMUST S1 17.pdf
