Status of vitamin D-25 hydroxy ditamin D {25 (OH)} in patients with multiple myeloma
10.35460/2546-1621.2018-0021
- Author:
Donaryn V PASAMONTE
1
;
Flordeluna Z MESINA
2
Author Information
1. University of Santo Tomas Hospital, Internal Medicine Department, Section of Clinical Hematology
2. University of Santo Tomas, Department of Medicine and Pharmacology
- Publication Type:Journal Article
- MeSH:
Multiple Myeloma;
Calcifediol;
Vitamins
- From:
Journal of Medicine University of Santo Tomas
2019;3(1):277-281
- CountryPhilippines
- Language:English
-
Abstract:
Introduction :Multiple myeloma (MM) causes generalized bone loss leading to lytic bone lesions and
pathologic fractures. The increased osteoclast activity and reduced osteoblast function favors bone
resorption and decreased bone formation. Vitamin
D is vital in regulating calcium homeostasis and
osteoclast-mediated bone resorption. Defi ciency
of Vitamin D among MM patients may complicate
bone mineralization problems and fractures.
Objective:General Objective:To determine the status of Vitamin D in patients with multiple myeloma
Specific Objective: To determine the levels of Vitamin D, intact parathyroid hormone and ionized calcium among MM patients.
Methodology :This is a prospective, cross-sectional study which included patients who were 18
years old and above, male or female, diagnosed
with MM at the University of Santo Tomas Hospital,
with or without treatment. Excluded in the study were
those with Vitamin D and calcium supplementation.
Eligible subjects were extracted blood for Vitamin D assay, intact parathyroid hormone and ionized calcium.
Results:A total of 22 patients with MM were included in the study. Sixteen patients (72.7%) had
hypovitaminosis D. Among these sixteen patients,
seven (31.8%) had Vitamin D defi ciency (Vitamin
D levels <20 ng/mL [50 nmol/L]) and nine (40.9%)
had Vitamin D insuffi ciency (levels of 21-29 ng/
mL [52.5-72.5 nmol/L]). Only 6 (27.3%) of them
were found to have normal serum Vitamin D (levels of >29 ng/mL [>72.5 nmol/L]). The mean age
(p=0.069), intact PTH (p=0.062) and ionized calcium (p=0.188) of the three groups of patients did
not differ
Conclusion :This study found a high incidence of
Vitamin D defi ciency among MM patients seen at
the University of Santo Tomas Hospital. Vitamin D
defi ciency was independent of age, intact PTH and
ionized calcium. It was more common in male subjects. Patients with hypovitaminosis D are at risk of
having secondary hyperparathyroidism.
Recommendation :Vitamin D status should be determined among patients with MM. Early recognition and treatment of hypovitaminosis D will prevent
the risk of having secondary hyperparathyroidism
that can complicate skeletal-related events.
- Full text:1 JMUST 4.pdf
