Hemostatic Effect of Fibrin Sealant Powder on Rabbit Liver Wound Surface and Optimized Dosage
- VernacularTitle:纤维蛋白胶干粉对兔肝创面的止血效果及应用剂量
- Author:
Da-tai WANG
;
Shu-zhong GUO
;
Xu-dong ZHANG
;
Yunzhi NI
- Publication Type:Journal Article
- Keywords:
fibrin sealant, powder, hemostasis, dosage
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(4):307-308
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the hemostatic effect of fibrin sealant (FS) powder on severe wound surface and find out the minimum effective dosage.Methods1 cm2 round wound surface was made on the liver of New Zealand white rabbits. Different dosages of FS powder were administrated on the wound surface. Bleeding time and bleeding volume were examined to find out optimized dosage. Hemostatic effect of FS powder was observed and compared with chitin cotton, gelfoam and normal gauze.ResultsBleeding time (0.57±0.21 min)and bleeding volume (0.35±0.29 ml)of FS 10 mg/cm2 group were obviously different from FS 8 mg/cm2 group (P<0.05), not significantly different from FS 12 mg/cm2 group. FS 10 mg/cm2 group got the shortest bleeding time and the lowest bleeding volume, which was obviously different from chitin cotton, gelfoam and gauze groups (P<0.05～0.01).ConclusionThe hemostatic effect of FS powder is better than gelfoam, chitin cotton and gauze and its optimized dosage is 10 mg/cm2.
