Quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiography
10.3980/j.issn.1672-5123.2023.6.30
- VernacularTitle:OCTA定量分析糖尿病视网膜病变患者黄斑区微循环变化
- Author:
Xin LU
1
,
2
;
Xing-Xing ZHAO
1
,
2
;
En-Hui YI
1
,
2
;
Yi-Ping ZHANG
1
,
2
;
Lu YU
1
,
2
;
Xiao-Kang HE
1
,
2
;
Ye ZHANG
1
,
2
;
Zhao-Jiang DU
1
,
2
Author Information
1. Department of Ophthalmology, Xi'an Central Hospital, Xi'an 710005, Shaanxi Province, China
2. Yan'an University, Yan'an 716000, Shaanxi Province, China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
optical coherence tomography angiography;
vascular density;
macular microcirculation;
foveal avascular zone
- From:
International Eye Science
2023;23(6):1033-1039
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the macular microcirculation changes in patients with diabetic retinopathy(DR)by optical coherence tomography angiography(OCTA), and correlate the risk factors that may affect the macular microcirculation, so as to provide a clinical basis for early screening, diagnosis and therapeutic intervention for DR.METHODS: Retrospective study. A total of 75 patients(75 eyes)with type 2 diabetes mellitus(DM)who came to the ophthalmology outpatient clinic and ward of Xi'an Central Hospital from May to October 2022 were collected, and the DM patients were further divided into non-DR(NDR)group, non-proliferative DR(NPDR)group and proliferative DR(PDR)group, with 28 eyes, 25 eyes and 22 eyes in each group respectively. OCTA was applied to perform a 3mm×3mm blood flow imaging scan of the macular retina to automatically obtain the vascular density(VD)of the superficial retinal macular foveal, the parafoveal(1～3mm), as well as the macular 3mm×3mm and the area of macular foveal avascular zone(FAZ). Furthermore, the alteration of these parameters in patients with different degrees of DR was analyzed.RESULTS: Compared with the NDR group, the VD of the 3mm×3mm superficial retinal capillary(SCP)in the macular region was decreased in both PDR and NPDR group(all P<0.017), and the VD of the parafoveal was decreased in each quadrant(P<0.017), with the most significant decrease in the PDR group. The FAZ area of patients in the PDR and NPDR groups was significantly larger than that in the NDR group(P<0.017). Age, homocysteine, best corrected visual acuity(LogMAR), axial length and glycosylated hemoglobin(HbA1c)of patients with DR were negatively correlated with VD in the macular foveal(P<0.05), while homocysteine, best corrected visual acuity(LogMAR), axial length, and the duration of diabetes were negatively correlated with VD in the macular 3mm×3mm(P<0.05). Triglycerides, best corrected visual acuity(LogMAR), and HbA1c were negatively correlated with VD in the parafoveal(P<0.05), while total cholesterol and central macular thickness had no significant correlation with VD(P>0.05).CONCLUSION: The microcirculation changes in the macular area of DR patients can be monitored by OCTA, and the systemic condition of DR patients is closely related to their macular microcirculation.
