Anti-tumor Effect of Alkaloids of Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20230425
- VernacularTitle:中药生物碱抗肿瘤作用研究进展
- Author:
Xinyue LIU
1
;
Lele CHEN
1
;
Peng SUN
1
;
Zhaoshuang ZHAN
1
;
Jiafeng WANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine， Jinan 250355， China
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
alkaloids;
anti-tumor;
derivatives;
nano-preparations;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(13):264-272
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors， with the increasing crude morbidity and mortality year by year， have become the major diseases threatening human health. The conventional therapeutic drugs against tumors have serious adverse reactions， which can cause a heavy burden on patients. The active components of Chinese medicine can effectively inhibit tumor growth， improve the quality of life of patients， and have few toxic and side effects. Alkaloids of Chinese medicine are natural organic compounds widely existing in a variety of Chinese herbal medicines. In recent years， they have attracted more and more attention because of their anti-tumor effect. The anti-tumor mechanisms of alkaloids of Chinese medicine mainly include the induction of apoptosis， inhibition of tumor cell migration and invasion， suppression of proliferation， induction of autophagy of tumor cells， cell cycle arrest， inhibition of tumor angiogenesis， regulation of microRNA， and modulation of immunity. In addition， Chinese medicine alkaloids can also reverse tumor drug resistance and reduce the stemness of tumor stem cells. Alkaloids of Chinese medicine can regulate the phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt）， c-Jun N-terminal kinase （JNK）， p38 mitogen-activated protein kinase （p38 MAPK）， mammalian target of rapamycin （mTOR）， Notch， Hedgehog， Wnt/β-catenin， and other signaling pathways to participate in the processes of tumor proliferation， invasion and metastasis， autophagy and apoptosis， and affect the occurrence and development of tumors in multiple links and ways. The derivatives and nano-preparations of alkaloids can improve the solubility， utilization， and anti-tumor activity of alkaloids， bringing a broader prospect for the clinical application of alkaloids. This review summarized the recent anti-tumor research on alkaloids， their representative derivatives， and nano-preparations to provide references for the in-depth research on the anti-tumor effect of alkaloids.
