Traditional Chinese Medicine in Treatment of Myocardial Ischemia-Reperfusion Injury by Regulating Adenosine 5'-monophosphate （AMP）-activated Protein Kinase： A Review
10.13422/j.cnki.syfjx.20230890
- VernacularTitle:中医药调控AMPK信号通路治疗心肌缺血再灌注损伤研究进展
- Author:
Yaqi HU
1
;
Jianhe LIU
2
Author Information
1. Hunan University of Chinese Medicine，Changsha 410208，China
2. The First Hospital of Hunan University of Chinese Medicine，Changsha 410007，China
- Publication Type:Journal Article
- Keywords:
adenosine 5'-monophosphate （AMP）-activated protein kinase （AMPK） signaling pathway;
traditional Chinese medicine;
myocardial ischemia reperfusion injury;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(13):213-221
- CountryChina
- Language:Chinese
-
Abstract:
Due to its high incidence and mortality rate， acute myocardial infarction poses a serious threat to public health. Reperfusion therapy is the preferred treatment strategy for acute myocardial infarction， which can quickly restore blood circulation to the ischemic myocardium， rescue dying myocardial cells， reduce infarct size， and lower the mortality rate. However， reperfusion may lead to additional heart damage， known as myocardial ischemia-reperfusion injury （MIRI）. Therefore， how to alleviate MIRI has become one of the urgent issues in cardiovascular therapy. Traditional Chinese medicine （TCM） has the advantage of multiple components， multiple pathways， and multiple targets in the treatment of MIRI， providing new ideas for reducing MIRI. Adenosine 5'-monophosphate （AMP）-activated protein kinase （AMPK） is closely related to MIRI， and it plays an important role in alleviating MIRI by regulating inflammation， oxidative stress， autophagy， apoptosis， and ferroptosis. This article reviewed the basic structure of the AMPK signaling pathway and its role in MIRI， as well as the research progress of TCM in the treatment of MIRI by regulating the AMPK pathway， aiming to provide a theoretical basis for the prevention and treatment of MIRI.
