Prevention and Treatment of Diabetic Peripheral Neuropathy by Chinese Medicine Through PI3K/Akt Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20232195
- VernacularTitle:中医药通过PI3K/Akt信号通路防治糖尿病周围神经病变的研究进展
- Author:
Jiushu YUAN
1
;
Yangming ZHOU
2
;
Xueru WANG
1
;
Susu HUANG
1
;
Hong GAO
1
;
Lian DU
3
Author Information
1. Affiliated Hospital of Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610032，China
2. Sichuan Second Hospital of TCM，Chengdu 610014，China
3. School of Basic Medicine，Chengdu University of TCM，Chengdu 611137，China
- Publication Type:Review
- Keywords:
traditional Chinese medicine;
diabetic peripheral neuropathy;
phosphatidylinositol 3-kinase（Pl3K）/protein kinase（Akt） signaling pathway;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(13):203-212
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic peripheral neuropathy （DPN） is characterized by insidious onset， easy misdiagnosis， and progression to severe consequences such as diabetic foot ulcers， gangrene， and amputation. The main pathological features of DPN are nerve cell injuries， such as axonal degeneration and necrosis， segmental demyelination of nerve fibers， and apoptosis of Schwann cells. The phosphoinositide 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway is a classical pathway that communicates intracellular and extracellular information and regulates biological activities such as cell proliferation， differentiation， apoptosis， autophagy， and migration. It widely affects various cells related to DPN. In recent years， numerous studies have found that the sustained high glucose environment causes abnormalities in the PI3K/Akt signaling pathway. This， in turn， accelerates the occurrence and development of DPN by participating in the pathogenesis of DPN， such as glucose and lipid metabolism， oxidative stress， inflammation， autophagy， apoptosis， and angiogenesis. Therefore， regulating the PI3K/Akt signaling pathway is crucial for the treatment of DPN. Currently， there is a lack of effective measures to slow down or reverse DPN in clinical practice. Traditional Chinese medicine （TCM） has unique advantages in preventing and treating DPN with multiple targets， effects， and components. A large number of animal and clinical studies of TCM treatment of DPN have shown that the PI3K/Akt signaling pathway is an important target for TCM treatment of DPN. Regulating the PI3K/Akt signaling pathway can promote myelin sheath repair and regeneration， delay the process of nerve cell death， and play a role in preventing and treating DPN. However， there is currently no systematic review and summary of this field in China and abroad. Therefore， this article summarized the regulation of the PI3K/Akt signaling pathway and its role in the pathogenesis of DPN， as well as the intervention of effective components of single Chinese medicine or compounds on the PI3K/Akt signaling pathway. This study is expected to provide a reference for the clinical diagnosis and treatment of DPN with TCM， basic research， and drug development.
