Role of type 2 innate lymphoid cells in helminth infections: a review
10.16250/j.32.1374.2022041
- VernacularTitle:2型固有淋巴细胞在蠕虫感染中的作用研究进展
- Author:
Yuxuan YANG
1
,
2
;
Zhixin WANG
1
,
2
;
Binjie WU
3
;
Shilei CHENG
3
;
Haining FAN
1
,
2
Author Information
1. Department of Hepatopancreatobiliary Surgery, The Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, China
2. Qinghai Provincial Key Laboratory for Echinococcosis Research, Xining, Qinghai 810001, China
3. Qinghai Provincial Key Laboratory for Echinococcosis Research, Xining, Qinghai 810001, China
- Publication Type:Journal Article
- Keywords:
Helminth;
Group 2 innate lymphoid cell;
Immune regulation
- From:
Chinese Journal of Schistosomiasis Control
2023;35(2):184-190
- CountryChina
- Language:Chinese
-
Abstract:
Helminth infections may trigger host innate and adaptive immune responses. Group 2 innate lymphoid cells (ILC2) are an important factor involved in type 2 immune responses, and produce a large number of T helper 2 cell (Th2) cytokines following stimulation by interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), which play a critical role in parasite clearance and tissue repair. Following helminth infections, autocrine factors, mast cells, enteric nervous system and Th2 cells have been recently found to be involved in regulation of ILC2. Unraveling the role of ILC2 in immune response against helminth infections is of great value for basic research and drug development. This review summarizes the research progress on ILC2 and its role in helminth infections.
